ZFHX3

ZFHX3
Identifiers
Aliases	ZFHX3, ATBF1, ATBT, ZNF927, zinc finger homeobox 3
External IDs	OMIM: 104155; MGI: 99948; GeneCards: ZFHX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DA1, 2DA2, 2DA3
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.2-q22.3 Start 72,782,885 bp End 73,891,871 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 D3 Start 108,669,276 bp End 109,688,262 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein buccal mucosa cell synovial joint tendon of biceps brachii lateral nuclear group of thalamus pericardium urethra mucosa of paranasal sinus trigeminal ganglion spinal ganglia Top expressed in ascending aorta aortic valve external carotid artery lacrimal gland internal carotid artery tunica media of zone of aorta vestibular membrane of cochlear duct ciliary body superior cervical ganglion lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity zinc ion binding metal ion binding core promoter sequence-specific DNA binding protein binding nucleic acid binding enzyme binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nuclear body transcription regulator complex nucleus nucleoplasm Biological process negative regulation of myoblast differentiation regulation of transcription, DNA-templated regulation of locomotor rhythm muscle organ development transcription by RNA polymerase II circadian regulation of gene expression transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of myoblast differentiation negative regulation of transcription, DNA-templated response to transforming growth factor beta negative regulation of transcription by RNA polymerase II brain development regulation of neuron differentiation positive regulation of cell adhesion positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 463 11906 Ensembl ENSG00000140836 ENSMUSG00000038872 UniProt Q15911 Q61329 RefSeq (mRNA) NM_001164766 NM_006885 NM_007496 RefSeq (protein) NP_001158238 NP_008816 n/a Location (UCSC) Chr 16: 72.78 – 73.89 Mb Chr 8: 108.67 – 109.69 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger homeobox protein 3 is a protein that in humans is encoded by the ZFHX3 gene.

Function

This protein is a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. It suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A. The gene ZFHX3 is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation.

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Further reading

External links

• ATBF1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human ZFHX3 genome location and ZFHX3 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by adding missing information.

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