TNFSF8

Search for
Structures	Swiss-model
Domains	InterPro

tumor necrosis factor (ligand) superfamily, member 8
tumor necrosis factor (ligand) superfamily, member 8
Identifiers
Symbol	TNFSF8
Alt. symbols	CD30LG
NCBI gene	944
HGNC	11938
OMIM	603875
RefSeq	NM_001244
UniProt	P32971
Other data
Locus	Chr. 9 q33
Structures
Search for
Structures	Swiss-model
Domains	InterPro

TNFSF8
Identifiers
Aliases	TNFSF8, CD153, CD30L, CD30LG, TNLG3A, tumor necrosis factor superfamily member 8, TNF superfamily member 8
External IDs	OMIM: 603875; MGI: 88328; GeneCards: TNFSF8
Gene location (Human)
Chr.	Chromosome 9 (human)
End	114,930,595 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	63,779,584 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; lymph node; ; appendix; ; superficial temporal artery; ; spleen; ; gallbladder; ; bone marrow; ; amniotic fluid;
	Top expressed in
	lymph node; ; intestinal villus; ; blood; ; thymus; ; jejunum; ; mesenteric lymph nodes; ; spleen; ; lumbar subsegment of spinal cord; ; carotid body; ; extraocular muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	tumor necrosis factor receptor binding; cytokine activity; signaling receptor binding;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; extracellular space; plasma membrane;
Biological process	CD8-positive, alpha-beta T cell differentiation; cell-cell signaling; cell population proliferation; immune response; signal transduction; positive regulation of transcription by RNA polymerase II; defense response to Gram-positive bacterium; apoptotic process; tumor necrosis factor-mediated signaling pathway; regulation of signaling receptor activity; regulation of T cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	944
	21949
	ENSG00000106952
	ENSMUSG00000028362
	P32971; Q52M88
	P32972
	NM_001252290; NM_001244
	NM_009403
	NP_001235; NP_001239219; NP_001235.1; NP_001239219.1
	NP_033429
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor ligand superfamily member 8, also known as cluster of differentiation 153 (CD153), is a protein that in humans is encoded by the TNFSF8 gene.

CD153 is a cytokine ligand for the TNF receptor CD30. It plays a role in the T cell-dependent anti-mycobacterial immune response.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000106952 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028362 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Marín ND, García LF (January 2017). "The role of CD30 and CD153 (CD30L) in the anti-mycobacterial immune response". Tuberculosis (Edinburgh, Scotland). 102: 8–15. doi:10.1016/j.tube.2016.10.006. PMID 28061955.

External links

CD153+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000106952 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028362 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Marín_2017-5] Marín ND, García LF (January 2017). "The role of CD30 and CD153 (CD30L) in the anti-mycobacterial immune response". Tuberculosis (Edinburgh, Scotland). 102: 8–15. doi:10.1016/j.tube.2016.10.006. PMID 28061955.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	1 a-c 1A 1B 1D 1E 2 3 γ δ ε 4 5 6 7 8 a 9 10 11 a b c d 13 14 15 16 A B 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 A B 33 34 35 36 37 38 39 40 41 42 a b c d 43 44 45 46 47 48 49 a b c d e f 50
51–100	51 52 53 54 55 56 57 58 59 61 62 E L P 63 64 A B C 66 a b c d e f 68 69 70 71 72 73 74 78 79 a b 80 81 82 83 84 85 a d e h j k 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100
101–150	101 102 103 104 105 106 107 a b 108 109 110 111 112 113 114 115 116 117 118 119 120 a b 121 a b 122 123 124 125 126 127 129 130 131 132 133 134 135 136 137 138 140b 141 142 143 144 146 147 148 150
151–200	151 152 153 154 155 156 a b c 157 158 (a d e i k) 159 a c 160 161 162 163 164 166 167 a b 168 169 170 171 172 a b g 174 177 178 179 a b 180 181 182 183 184 185 186 191 192 193 194 195 196 197 w198 w199 200
201–250	201 202b 204 205 206 207 208 209 w210 a b 212 213a 1 2 217 218 (a b) 220 221 222 223 224 225 226 227 228 229 230 233 234 235 a b 236 238 239 240CE 240D 241 243 244 246 247 248 249
251–300	252 253 254 256 257 258 261 262 263 264 265 266 267 268 269 271 272 273 274 275 276 278 279 280 281 282 283 284 286 288 289 290 292 w293 294 295 297 298 299
301–350	300A 301 302 303 304 305 306 307 309 312 314 315 316 317 318 320 321 322 324 325 326 327 328 329 331 332 333 334 335 336 337 338 339 340 344 349 350
351–371	351 352 353 354 355 357 358 360 361 362 363 364 365 366 367 368 369 370 371
Category Commons