SDC3

SDC3
Identifiants
Alias	SDC3
IDs externes	OMIM: 186357 MGI: 1349163 HomoloGene: 7965 GeneCards: SDC3
Position du gène (humain)
Chr.	Chromosome 1 humain
Fin	30,908,758 bp
Position du gène (souris)
Chr.	Chromosome 4 (souris)
Fin	130,553,630 bp
Expression génique
	Fortement exprimé dans
	right adrenal cortex; ; left adrenal cortex; ; noyau accumbens; ; amygdale; ; noyau caudé; ; cortex cingulaire antérieur; ; hypothalamus; ; putamen; ; right frontal lobe; ; left uterine tube;
	Fortement exprimé dans
	calvaria; ; stroma of bone marrow; ; glande surrénale; ; molaire; ; dentate gyrus of hippocampal formation granule cell; ; corps du fémur; ; ganglion mésentérique; ; cortex visuel; ; épithélium olfactif; ; primary visual cortex;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison protéique; identical protein binding;
Composant cellulaire	integral component of membrane; membrane; membrane plasmique; lysosomal lumen; Golgi lumen; surface cellulaire; matrice extracellulaire; collagen-containing extracellular matrix; microspike;
Processus biologique	glycosaminoglycan metabolic process; retinoid metabolic process; glycosaminoglycan catabolic process; glycosaminoglycan biosynthetic process; leukocyte migration; migration cellulaire;
	Sources:Amigo / QuickGO
Orthologues
	9672
	20970
	ENSG00000162512
	ENSMUSG00000025743
	O75056
	Q64519
	NM_014654
	NM_011520
	NP_055469
	NP_035650
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le syndécan-3 est une protéine qui, chez l'être humain, est codée par le gène SDC3^,^,.

Notes et références

(en) Cet article est partiellement ou en totalité issu de l’article de Wikipédia en anglais intitulé « Syndecan-3 » (voir la liste des auteurs).

1 2 3 GRCh38: Ensembl release 89: ENSG00000162512 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025743 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Molecular cloning and characterization of N-syndecan, a novel transmembrane heparan sulfate proteoglycan », J Cell Biol, vol. 117, n^o 1,‎ mai 1992, p. 191–201 (PMID 1556152, PMCID 2289399, DOI 10.1083/jcb.117.1.191)
↑ « Cloning and characterization of human syndecan-3 », J Cell Biochem, vol. 82, n^o 2,‎ août 2001, p. 246–59 (PMID 11527150, DOI 10.1002/jcb.1119, S2CID 1870905)
↑ « Entrez Gene: SDC3 syndecan 3 »

Bibliographie

Barillari G, Gendelman R, Gallo RC, Ensoli B, « The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. », Proc. Natl. Acad. Sci. U.S.A., vol. 90, n^o 17,‎ 1993, p. 7941–5 (PMID 7690138, PMCID 47263, DOI 10.1073/pnas.90.17.7941 , Bibcode 1993PNAS...90.7941B)
Raulo E, Chernousov MA, Carey DJ, etal, « Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3). », J. Biol. Chem., vol. 269, n^o 17,‎ 1994, p. 12999–3004 (PMID 8175719, DOI 10.1016/S0021-9258(18)99975-8 )
Chernousov MA, Carey DJ, « N-syndecan (syndecan 3) from neonatal rat brain binds basic fibroblast growth factor. », J. Biol. Chem., vol. 268, n^o 22,‎ 1993, p. 16810–4 (PMID 8344959, DOI 10.1016/S0021-9258(19)85488-1 )
Albini A, Benelli R, Presta M, etal, « HIV-tat protein is a heparin-binding angiogenic growth factor. », Oncogene, vol. 12, n^o 2,‎ 1996, p. 289–97 (PMID 8570206)
Chernousov MA, Stahl RC, Carey DJ, « Schwann cells secrete a novel collagen-like adhesive protein that binds N-syndecan. », J. Biol. Chem., vol. 271, n^o 23,‎ 1996, p. 13844–53 (PMID 8662884, DOI 10.1074/jbc.271.23.13844 )
Nakanishi T, Kadomatsu K, Okamoto T, etal, « Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine. », J. Biochem., vol. 121, n^o 2,‎ 1997, p. 197–205 (PMID 9089390)
Rusnati M, Coltrini D, Oreste P, etal, « Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size. », J. Biol. Chem., vol. 272, n^o 17,‎ 1997, p. 11313–20 (PMID 9111037, DOI 10.1074/jbc.272.17.11313 )
Chang HC, Samaniego F, Nair BC, etal, « HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region. », AIDS, vol. 11, n^o 12,‎ 1997, p. 1421–31 (PMID 9342064, DOI 10.1097/00002030-199712000-00006 , S2CID 7648619)
Asundi VK, Carey DJ, « Phosphorylation of recombinant N-syndecan (syndecan 3) core protein. », Biochem. Biophys. Res. Commun., vol. 240, n^o 2,‎ 1997, p. 502–6 (PMID 9388509, DOI 10.1006/bbrc.1997.7684)
Seki N, Ohira M, Nagase T, etal, « Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. », DNA Res., vol. 4, n^o 5,‎ 1998, p. 345–9 (PMID 9455484, DOI 10.1093/dnares/4.5.345 )
Kinnunen T, Kaksonen M, Saarinen J, etal, « Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth. », J. Biol. Chem., vol. 273, n^o 17,‎ 1998, p. 10702–8 (PMID 9553134, DOI 10.1074/jbc.273.17.10702 )
Hsueh YP, Sheng M, « Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development. », J. Neurosci., vol. 19, n^o 17,‎ 1999, p. 7415–25 (PMID 10460248, PMCID 6782500, DOI 10.1523/JNEUROSCI.19-17-07415.1999 )
Rusnati M, Tulipano G, Spillmann D, etal, « Multiple interactions of HIV-I Tat protein with size-defined heparin oligosaccharides. », J. Biol. Chem., vol. 274, n^o 40,‎ 1999, p. 28198–205 (PMID 10497173, DOI 10.1074/jbc.274.40.28198 )
Tyagi M, Rusnati M, Presta M, Giacca M, « Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans. », J. Biol. Chem., vol. 276, n^o 5,‎ 2001, p. 3254–61 (PMID 11024024, DOI 10.1074/jbc.M006701200 )
Koroll M, Rathjen FG, Volkmer H, « The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. », J. Biol. Chem., vol. 276, n^o 14,‎ 2001, p. 10646–54 (PMID 11152476, DOI 10.1074/jbc.M010647200 )
Hakansson S, Jacobs A, Caffrey M, « Heparin binding by the HIV-1 tat protein transduction domain. », Protein Sci., vol. 10, n^o 10,‎ 2001, p. 2138–9 (PMID 11567105, PMCID 2374215, DOI 10.1110/ps.23401)
Erdman R, Stahl RC, Rothblum K, etal, « Schwann cell adhesion to a novel heparan sulfate binding site in the N-terminal domain of alpha 4 type V collagen is mediated by syndecan-3. », J. Biol. Chem., vol. 277, n^o 9,‎ 2002, p. 7619–25 (PMID 11751872, DOI 10.1074/jbc.M111311200 )
Alvarez K, Fadic R, Brandan E, « Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy. », J. Cell. Biochem., vol. 85, n^o 4,‎ 2002, p. 703–13 (PMID 11968010, DOI 10.1002/jcb.10184, hdl 10533/173369 , S2CID 20243469)

Portail de la biologie cellulaire et moléculaire

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162512 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025743 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[pmid1556152-5] « Molecular cloning and characterization of N-syndecan, a novel transmembrane heparan sulfate proteoglycan », J Cell Biol, vol. 117, n^o 1,‎ mai 1992, p. 191–201 (PMID 1556152, PMCID 2289399, DOI 10.1083/jcb.117.1.191)

[pmid11527150-6] « Cloning and characterization of human syndecan-3 », J Cell Biochem, vol. 82, n^o 2,‎ août 2001, p. 246–59 (PMID 11527150, DOI 10.1002/jcb.1119, S2CID 1870905)

[entrez-7] « Entrez Gene: SDC3 syndecan 3 »